2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Monocarboxylate Transporter
  5. Monocarboxylate Transporter Isoform
  6. Monocarboxylate Transporter Inhibitor

Monocarboxylate Transporter Inhibitor

Monocarboxylate Transporter Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-139665
    VB124
    		Inhibitor 99.86%
    VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism.
  • HY-107641
    α-Cyano-4-hydroxycinnamic acid
    		Inhibitor 99.98%
    α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications.
  • HY-D0713
    7ACC2
    		Inhibitor 99.62%
    7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux.
  • HY-150314
    MCT-IN-1
    		Inhibitor ≥98.0%
    MCT-IN-1 (compound 2) is a potent inhibitor of monocarboxylate transporter (MCT), with the IC50 of 9 nM and 14 nM for MCT1 and MCT4, respectively.
  • HY-119996A
    AR-C141990 hydrochloride
    		Inhibitor ≥98.0%
    AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pKi values of 7.6, 6.6 for MCT-1 and MCT-2, respectively. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response.
  • HY-160107
    AZ1422
    		Inhibitor
    AZ1422 is a selective MCT4 inhibitor that can be used in cancer research.
  • HY-148574
    MCT1-IN-3
    		Inhibitor
    MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer.