2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Monocarboxylate Transporter
  5. Monocarboxylate Transporter Isoform
  6. Monocarboxylate Transporter Inhibitor

Monocarboxylate Transporter Inhibitor

Monocarboxylate Transporter Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-107641
    α-Cyano-4-hydroxycinnamic acid
    		Inhibitor 99.98%
    α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications.
  • HY-D0713
    7ACC2
    		Inhibitor 99.62%
    7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux.
  • HY-150314
    MCT-IN-1
    		Inhibitor ≥98.0%
    MCT-IN-1 (compound 2) is a potent inhibitor of monocarboxylate transporter (MCT), with the IC50 of 9 nM and 14 nM for MCT1 and MCT4, respectively.
  • HY-119996A
    AR-C141990 hydrochloride
    		Inhibitor ≥98.0%
    AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pKi values of 7.6, 6.6 for MCT-1 and MCT-2, respectively. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response.
  • HY-114602
    AR-C117977
    		Inhibitor
    AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse.
  • HY-160107
    AZ1422
    		Inhibitor
    AZ1422 is a selective MCT4 inhibitor that can be used in cancer research.
  • HY-148574
    MCT1-IN-3
    		Inhibitor
    MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer.